Potential Benefits of Therapeutic Use of β2-Adrenergic Receptor Agonists in Neuroprotection and Parkinsonμs Disease
Identifieur interne : 000967 ( Main/Exploration ); précédent : 000966; suivant : 000968Potential Benefits of Therapeutic Use of β2-Adrenergic Receptor Agonists in Neuroprotection and Parkinsonμs Disease
Auteurs : Lynda Peterson [États-Unis] ; Kathleen P. Ismond [Canada] ; Elisha Chapman [Canada] ; Patrick Flood [Canada, États-Unis]Source :
- Journal of Immunology Research [ 2314-8861 ] ; 2014.
English descriptors
- KwdEn :
- Adrenergic beta-2 Receptor Agonists (pharmacology), Adrenergic beta-2 Receptor Agonists (therapeutic use), Animals, Humans, Immune System (drug effects), Immune System (metabolism), Neuroprotective Agents (pharmacology), Neuroprotective Agents (therapeutic use), Parkinson Disease (drug therapy), Parkinson Disease (immunology), Parkinson Disease (metabolism), Receptors, Adrenergic, beta-2 (metabolism), Signal Transduction (drug effects).
- MESH :
- chemical , metabolism : Receptors, Adrenergic, beta-2.
- chemical , pharmacology : Adrenergic beta-2 Receptor Agonists, Neuroprotective Agents.
- chemical , therapeutic use : Adrenergic beta-2 Receptor Agonists, Neuroprotective Agents.
- drug effects : Immune System, Signal Transduction.
- drug therapy : Parkinson Disease.
- immunology : Parkinson Disease.
- metabolism : Immune System, Parkinson Disease.
- Animals, Humans.
Abstract
The
Url:
DOI: 10.1155/2014/103780
PubMed: 24741572
PubMed Central: 3987873
Affiliations:
- Canada, États-Unis
- Caroline du Nord
- Chapel Hill (Caroline du Nord)
- Université de Caroline du Nord à Chapel Hill
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Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Potential Benefits of Therapeutic Use of <bold><italic><italic>β</italic>
</italic>
2</bold>
-Adrenergic Receptor Agonists in Neuroprotection and Parkinson<italic><italic>μ</italic>
</italic>
s Disease</title>
<author><name sortKey="Peterson, Lynda" sort="Peterson, Lynda" uniqKey="Peterson L" first="Lynda" last="Peterson">Lynda Peterson</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Ismond, Kathleen P" sort="Ismond, Kathleen P" uniqKey="Ismond K" first="Kathleen P." last="Ismond">Kathleen P. Ismond</name>
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<country>Canada</country>
<wicri:regionArea>School of Dentistry, University of Alberta, 7020 Katz Group Centre, Edmonton, AB</wicri:regionArea>
<wicri:noRegion>AB</wicri:noRegion>
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<author><name sortKey="Chapman, Elisha" sort="Chapman, Elisha" uniqKey="Chapman E" first="Elisha" last="Chapman">Elisha Chapman</name>
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<wicri:noRegion>AB</wicri:noRegion>
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<wicri:noRegion>AB</wicri:noRegion>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>North Carolina Oral Health Institute, School of Dentistry, The University of North Carolina at Chapel Hill, Manning Dr. & Columbia Street, Campus Box 7450, Chapel Hill, NC 27599-7450</wicri:regionArea>
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<series><title level="j">Journal of Immunology Research</title>
<idno type="ISSN">2314-8861</idno>
<idno type="eISSN">2314-7156</idno>
<imprint><date when="2014">2014</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenergic beta-2 Receptor Agonists (pharmacology)</term>
<term>Adrenergic beta-2 Receptor Agonists (therapeutic use)</term>
<term>Animals</term>
<term>Humans</term>
<term>Immune System (drug effects)</term>
<term>Immune System (metabolism)</term>
<term>Neuroprotective Agents (pharmacology)</term>
<term>Neuroprotective Agents (therapeutic use)</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson Disease (immunology)</term>
<term>Parkinson Disease (metabolism)</term>
<term>Receptors, Adrenergic, beta-2 (metabolism)</term>
<term>Signal Transduction (drug effects)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Receptors, Adrenergic, beta-2</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Adrenergic beta-2 Receptor Agonists</term>
<term>Neuroprotective Agents</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Adrenergic beta-2 Receptor Agonists</term>
<term>Neuroprotective Agents</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Immune System</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Immune System</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Humans</term>
</keywords>
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<front><div type="abstract" xml:lang="en"><p>The <italic><italic>β</italic>
</italic>
2-adrenergic receptor (<italic><italic>β</italic>
</italic>
2AR) is a seven-transmembrane (7TM) G-protein coupled receptor that is expressed on cells of the pulmonary, cardiac, skeletal muscle, and immune systems. Previous work has shown that stimulation of this receptor on immune cells has profound effects on the regulatory activity of both adaptive and innate immune cells. This review examines the functional dichotomy associated with stimulation of <italic><italic>β</italic>
</italic>
2AR and microglial cells. As well, recent studies targeting these receptors with long-acting agonists are considered with respect to their therapeutic potential in management of Parkinson<italic><italic>μ</italic>
</italic>
s disease.</p>
</div>
</front>
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</div1>
</back>
</TEI>
<affiliations><list><country><li>Canada</li>
<li>États-Unis</li>
</country>
<region><li>Caroline du Nord</li>
</region>
<settlement><li>Chapel Hill (Caroline du Nord)</li>
</settlement>
<orgName><li>Université de Caroline du Nord à Chapel Hill</li>
</orgName>
</list>
<tree><country name="États-Unis"><noRegion><name sortKey="Peterson, Lynda" sort="Peterson, Lynda" uniqKey="Peterson L" first="Lynda" last="Peterson">Lynda Peterson</name>
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<name sortKey="Flood, Patrick" sort="Flood, Patrick" uniqKey="Flood P" first="Patrick" last="Flood">Patrick Flood</name>
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<country name="Canada"><noRegion><name sortKey="Ismond, Kathleen P" sort="Ismond, Kathleen P" uniqKey="Ismond K" first="Kathleen P." last="Ismond">Kathleen P. Ismond</name>
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<name sortKey="Chapman, Elisha" sort="Chapman, Elisha" uniqKey="Chapman E" first="Elisha" last="Chapman">Elisha Chapman</name>
<name sortKey="Flood, Patrick" sort="Flood, Patrick" uniqKey="Flood P" first="Patrick" last="Flood">Patrick Flood</name>
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</affiliations>
</record>
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